Synthesis and Neuropsychotropic Activity of Indole-Containing Gamma-Aminobutyric Acid Derivatives
- Authors: Berestovitskaya V.M.1, Vasil’eva O.S.1, Ostroglyadov E.S.1, Aleksandrova S.M.2, Tyurenkov I.N.3, Merkushenkova O.V.3, Bagmetova V.V.3
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Affiliations:
- Herzen State Pedagogical University of Russia
- Pskov State University
- Volgograd State Medical University
- Issue: Vol 52, No 5 (2018)
- Pages: 392-396
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245205
- DOI: https://doi.org/10.1007/s11094-018-1827-0
- ID: 245205
Cite item
Abstract
A series of indole-containing γ-aminobutyric acids (GABA) were synthesized via alkaline hydrolysis of 4-(indol-3-yl)-2-pyrrolidones. Their structures were confirmed by IR, PMR, and 13C NMR spectroscopy. Studies of the pharmacological properties of 4-amino-3-indolylbutanoic acids (GABA derivatives) showed that they possessed neuropsychotropic activity, the spectrum of which depended on the acid molecular structure. Nootropic properties prevailed for 4-amino-3-(indol-3-yl)butanoic acid; anxiolytic activity, for 4-amino-3-(1-benzylindol-3-yl)butanoic acid.
About the authors
V. M. Berestovitskaya
Herzen State Pedagogical University of Russia
Author for correspondence.
Email: kohrgpu@yandex.ru
Russian Federation, 48 nab. R. Moiki, St. Petersburg, 191186
O. S. Vasil’eva
Herzen State Pedagogical University of Russia
Email: kohrgpu@yandex.ru
Russian Federation, 48 nab. R. Moiki, St. Petersburg, 191186
E. S. Ostroglyadov
Herzen State Pedagogical University of Russia
Email: kohrgpu@yandex.ru
Russian Federation, 48 nab. R. Moiki, St. Petersburg, 191186
S. M. Aleksandrova
Pskov State University
Email: kohrgpu@yandex.ru
Russian Federation, 2 Lenin Sq., Pskov, 180000
I. N. Tyurenkov
Volgograd State Medical University
Email: kohrgpu@yandex.ru
Russian Federation, 1 Pavshikh Bortsov Sq., Volgograd, 400131
O. V. Merkushenkova
Volgograd State Medical University
Email: kohrgpu@yandex.ru
Russian Federation, 1 Pavshikh Bortsov Sq., Volgograd, 400131
V. V. Bagmetova
Volgograd State Medical University
Email: kohrgpu@yandex.ru
Russian Federation, 1 Pavshikh Bortsov Sq., Volgograd, 400131