Development and Validation of a Quantitative Determination Method for the Antitubercular Drug PBTZ169 in Biological Media
- Авторы: Stepanova E.1, Barsegyan S.1, Makarenkova L.1, Chistyakov V.1
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Учреждения:
- People’s Friendship University of Russia, Common Use Center
- Выпуск: Том 52, № 3 (2018)
- Страницы: 248-253
- Раздел: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245106
- DOI: https://doi.org/10.1007/s11094-018-1801-x
- ID: 245106
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Аннотация
An HPLC-MS/MS method for quantitative determination of the new antituberculosis drug PBTZ169 in blood serum, urine, and feces using perindopril as an internal standard was developed and validated. The method was selective, specific, accurate, and precise. Calibration curves were linear in the ranges 2 – 2,000, 5 – 3,000, and 100 – 10,000 ng/mL for blood serum, urine, and feces, respectively, with correlation coefficients >0.99. The detection limits of PBTZ169 were 1, 2.5, and 50 ng/mL for serum, urine, and feces, respectively. The limits of quantitation were 2 ng/mL in serum; 5, urine; and 100, feces.
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E. Stepanova
People’s Friendship University of Russia, Common Use Center
Автор, ответственный за переписку.
Email: stepanova25@inbox.ru
Россия, Moscow, 117198
S. Barsegyan
People’s Friendship University of Russia, Common Use Center
Email: stepanova25@inbox.ru
Россия, Moscow, 117198
L. Makarenkova
People’s Friendship University of Russia, Common Use Center
Email: stepanova25@inbox.ru
Россия, Moscow, 117198
V. Chistyakov
People’s Friendship University of Russia, Common Use Center
Email: stepanova25@inbox.ru
Россия, Moscow, 117198