Anti-Candida Activity of 4-Morpholino-5-Nitro- and 4,5-Dinitro-Imidazole Derivatives
- Авторы: Olender D.1, Zaprutko L.1, Mertas A.2, Szliszka E.2, Wyrozumski D.2, Król W.2
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Учреждения:
- Department of Organic Chemistry, Poznan University of Medical Sciences
- Department of Microbiology and Immunology, Medical University of Silesia in Katowice
- Выпуск: Том 51, № 12 (2018)
- Страницы: 1063-1067
- Раздел: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244914
- DOI: https://doi.org/10.1007/s11094-018-1741-5
- ID: 244914
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Аннотация
The activities of some 4-morpholino-5-nitro- and 4,5-dinitro-imidazole derivatives with respect to several Candida species were evaluated. It is established that 4,5-dinitroimidazole derivatives constitute an important group of compounds possessing antifungal activity against Candida species. Some analogs showed moderate antifungal ability in vitro, especially in relation well-known antifungals such as flucytosine (5FC). The best results of antifungal action were obtained for 1-(3-bromo-2-hydroxypropyl)-2-methyl-4,5-dinitroimidazole (3c), 1-(3-bromo-2-oxopropyl)-2-methyl-4,5-dinitroimidazole (4c) and 2-methyl-1-phenacyl-4,5-dinitroimidazole (2b). The latter compound proved to be effective against Candida sake S-1 (in contrast to inactive 5FC).
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Об авторах
Dorota Olender
Department of Organic Chemistry, Poznan University of Medical Sciences
Автор, ответственный за переписку.
Email: dolender@ump.edu.pl
Польша, Grunwaldzka 6, Poznań, 60 – 780
Lucjusz Zaprutko
Department of Organic Chemistry, Poznan University of Medical Sciences
Email: dolender@ump.edu.pl
Польша, Grunwaldzka 6, Poznań, 60 – 780
Anna Mertas
Department of Microbiology and Immunology, Medical University of Silesia in Katowice
Email: dolender@ump.edu.pl
Польша, Jordana 19, Zabrze, 41 – 808
Ewelina Szliszka
Department of Microbiology and Immunology, Medical University of Silesia in Katowice
Email: dolender@ump.edu.pl
Польша, Jordana 19, Zabrze, 41 – 808
Dariusz Wyrozumski
Department of Microbiology and Immunology, Medical University of Silesia in Katowice
Email: dolender@ump.edu.pl
Польша, Jordana 19, Zabrze, 41 – 808
Wojciech Król
Department of Microbiology and Immunology, Medical University of Silesia in Katowice
Email: dolender@ump.edu.pl
Польша, Jordana 19, Zabrze, 41 – 808