Enviar artigo por via de e-mail Cytotoxicity of New Ferulic-Acid Derivatives on Human Colon Carcinoma (HCT116) Cells
- Autores: Bakholdina L.1,2, Markova A.3, Khlebnikov A.4, Sevodin V.1
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Afiliações:
- Biisk Technological Institute (Filial), I. I. Polzunov Altai State Technical University
- Institute for Problems of Chemical and Energetic Technologies, Siberian Branch, Russian Academy of Sciences
- A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
- National Research Tomsk Polytechnic University
- Edição: Volume 53, Nº 6 (2019)
- Páginas: 516-520
- Seção: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245839
- DOI: https://doi.org/10.1007/s11094-019-02030-y
- ID: 245839
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Resumo
A series of esters of ferulic acid and alcohols were synthesized and characterized structurally. All tested synthetic compounds were more cytotoxic against HCT116 cell line (human colon carcinoma) than ferulic acid. Benzyl and phenylethyl esters of ferulic acid were the most active compounds (IC50 = 0.0077 and 0.0065 g/L, respectively). Feruloylated wheat-bran oligosaccharides were less active than free ferulic acid against HCT116 tumor cells.
Sobre autores
L. Bakholdina
Biisk Technological Institute (Filial), I. I. Polzunov Altai State Technical University; Institute for Problems of Chemical and Energetic Technologies, Siberian Branch, Russian Academy of Sciences
Autor responsável pela correspondência
Email: ljuba27@mail.ru
Rússia, 27 Trofimov St., Biisk, Altai Krai, 659305; Biisk, Altai Krai, 659322
A. Markova
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: ljuba27@mail.ru
Rússia, Moscow, 119991
A. Khlebnikov
National Research Tomsk Polytechnic University
Email: ljuba27@mail.ru
Rússia, Tomsk, 634050
V. Sevodin
Biisk Technological Institute (Filial), I. I. Polzunov Altai State Technical University
Email: ljuba27@mail.ru
Rússia, 27 Trofimov St., Biisk, Altai Krai, 659305
