Syntheses of Melanotan II and YSL Amide by Ajiphase® Methodology

Resumo

The promising antitumor peptides Melanotan II and YSL amide were synthesized for the first time in gram quantities in overall yields of 72 and 50%, respectively, by Ajiphase^® methodology. This method was shown to be promising for peptide manufacturing. The proposed methods are as convenient as polymer-phase syntheses with the reagent consumption and associated analytical simplicity of classical solution syntheses.