Synthesis, Structure, and Analgesic Activity of Picolylamides of 2-Hydroxy-4-Oxo-4H-Pyrido-[1,2-a]Pyrimidine-3-Carboxylic Acids
- Autores: Ukrainets I.1, Bereznyakova N.1, Sim G.2, Davidenko A.3
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Afiliações:
- National Pharmaceutical University
- Far East State Medical University
- N. I. Pirogov Vinnitsa National Medical University
- Edição: Volume 52, Nº 7 (2018)
- Páginas: 601-605
- Seção: The Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/245364
- DOI: https://doi.org/10.1007/s11094-018-1867-5
- ID: 245364
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Resumo
With the aim of establishing a structure-analgesic activity relationship, a series of picolylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]-pyrimidine-3-carboxylic acids were synthesized. The characteristics of the spatial structure of this group of substances were assessed. The results of pharmacological studies identified compounds in the study series with marked analgesic properties. However, it was noted that the transition from 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamides to the structurally similar pyrido[1,2-a]pyrimidine derivatives was generally accompanied by some decrease in analgesic activity.
Sobre autores
I. Ukrainets
National Pharmaceutical University
Autor responsável pela correspondência
Email: uiv-2@mail.ru
Ucrânia, Kharkov
N. Bereznyakova
National Pharmaceutical University
Email: uiv-2@mail.ru
Ucrânia, Kharkov
G. Sim
Far East State Medical University
Email: uiv-2@mail.ru
Rússia, Khabarovsk
A. Davidenko
N. I. Pirogov Vinnitsa National Medical University
Email: uiv-2@mail.ru
Ucrânia, Vinnitsa