Potential Biological Activity and Chemical Composition of Caragana Jubata (Pall.) Poir. (Review)

Resumo

Literature data on the chemical composition and biological activity of Caragana jubata (Pall.)Poir. (Fabaceae, bean), a new potential source of medicinal raw material that is widely used in Russian folk medicine, were reviewed. Preliminary experiments on the composition of biologically active compounds and the pharmacological activity of the aqueous extract of the aerial part of C. jubata were performed by us. An analysis of the literature data and our results led to the conclusion that polyphenolic compounds (flavonoids), primarily mono- and diglycoside derivatives of O-hydroxylated flavonols, were the dominant fraction of biologically active compounds from C. jubata. According to the literature, C. jubata could possess hepatoprotective and antiviral activity. In vitro antioxidant activity of the aqueous extract of the aerial part of C. jubata, anti-inflammatory and wound-healing activity, and a lack of antibacterial activity against several pharmacopeial strains were found in our research. C. jubata could be recommended for further preclinical and clinical trials for efficacy and safety as a potential medicinal plant based on the information analysis and experiments.