Development of an HPLC-MS/MS Method for Quantitative Determination of Rivaroxaban in Human Blood Serum
- Autores: Rodina T.1, Mel’nikov E.1, Aksenov A.1, Belkov S.1, Sokolov A.1, Prokof’ev A.1, Ramenskaya G.1
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Afiliações:
- Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Health of the Russian Federation
- Edição: Volume 52, Nº 4 (2018)
- Páginas: 372-377
- Seção: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245191
- DOI: https://doi.org/10.1007/s11094-018-1824-3
- ID: 245191
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Resumo
An HPLC-MS/MS method for determination of rivaroxaban in human blood serum was developed. Sample preparation included protein precipitation by MeOH followed by centrifugation and dilution with deionized H2O. The developed procedure had simple sample preparation, a short analysis time, and a wide analytical range (1.00 to 1,000.00 ng/mL). The procedure was convenient for routine bioanalytical studies, in particular, for therapeutic drug monitoring.
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Sobre autores
T. Rodina
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Rússia, 8/2 Petrovskii Blvd, Moscow, 127051
E. Mel’nikov
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Rússia, 8/2 Petrovskii Blvd, Moscow, 127051
A. Aksenov
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Rússia, 8/2 Petrovskii Blvd, Moscow, 127051
S. Belkov
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Rússia, 8/2 Petrovskii Blvd, Moscow, 127051
A. Sokolov
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Rússia, 8/2 Petrovskii Blvd, Moscow, 127051
A. Prokof’ev
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Rússia, 8/2 Petrovskii Blvd, Moscow, 127051
G. Ramenskaya
Scientific Centre for Expert Evaluation of Medicinal Products, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Rússia, 8/2 Petrovskii Blvd, Moscow, 127051