Possible Ways of Studying Pharmacokinetic Parameters of Calcium Preparations
- Autores: Eremenko N.1,2, Shikh E.1,2, Serebrova S.1,2, Goryachev D.1
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Afiliações:
- Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
- Sechenov First Moscow State Medical University
- Edição: Volume 52, Nº 3 (2018)
- Páginas: 195-197
- Seção: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245074
- DOI: https://doi.org/10.1007/s11094-018-1789-2
- ID: 245074
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Resumo
Issues pertaining to determination of the pharmacokinetic parameters of calcium preparations are examined using their comparative bioavailability as an example. Pharmacokinetic parameters of calcium such as area under the concentration—time curve (AUC) and maximum concentration (Cmax) are calculated considering the background calcium contents in volunteers. Calcium excretion with urine is assessed as clearance of creatinine, a calcium elimination factor. The dynamics of the content of parathormone (PTH), the main hormone regulating calcium homeostasis, are studied. The results can be used to plan clinical trials for assessing the pharmacokinetics of drug analogs of endogenous compounds.
Sobre autores
N. Eremenko
Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation; Sechenov First Moscow State Medical University
Autor responsável pela correspondência
Email: Eremenko@expmed.ru
Rússia, 8/2 Petrovskii Blvd., Moscow, 127051; 8/2 Trubetskaya St., Moscow, 119991
E. Shikh
Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation; Sechenov First Moscow State Medical University
Email: Eremenko@expmed.ru
Rússia, 8/2 Petrovskii Blvd., Moscow, 127051; 8/2 Trubetskaya St., Moscow, 119991
S. Serebrova
Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation; Sechenov First Moscow State Medical University
Email: Eremenko@expmed.ru
Rússia, 8/2 Petrovskii Blvd., Moscow, 127051; 8/2 Trubetskaya St., Moscow, 119991
D. Goryachev
Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: Eremenko@expmed.ru
Rússia, 8/2 Petrovskii Blvd., Moscow, 127051