Enviar artigo por via de e-mail The Search for Pharmacologically Active Compounds Among the 2-Dialkylaminobenzimidazoles
- Autores: Zhukovskaya O.1, Anisimova V.1, Spasov A.2,3, Yakovlev D.2,3, Gurova N.2, Kucheryavenko A.2, Salaznikova O.2, Kuznetsova V.2,3, Mal’tsev D.2,3, Brigadirova A.2,3, Morkovina Y.3, Solov’eva O.2, Gurova V.2, Reznikov E.2
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Afiliações:
- Science Research Institute of Physical and Organic Chemistry, Southern Federal University
- Volgograd State Medical University, Ministry of Health of the Russian Federation
- Volgograd Medical Scientific Center
- Edição: Volume 51, Nº 3 (2017)
- Páginas: 182-186
- Seção: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244525
- DOI: https://doi.org/10.1007/s11094-017-1578-3
- ID: 244525
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Resumo
Heating of substituted benzimidazole-2-sulfonic acids in the presence of excess quantities of secondary amines was used to synthesize dialkylaminobenzimidazoles. Experimental studies of potential antiarrhythmic, antiaggregation, hemorheological, AT1 angiotensin- and NHE-1-inhibiting, and antiserotonin activity identified active compounds. 1[-2-(5-Methyl)benzimidazole]pyrrolidine had greater NHE-inhibiting activity than zoniporide. 1-{[2-(5-Methoxy)benzimidazole]-4-N-methyl}piperazine dihydrochloride had greater antiaggregatory activity than acetylsalicylic acid, while 1-[2-(5-methyl)benzimidazole]piperidine was as active as cyproheptadine in terms of 5-HT2A antagonistic activity. 1-(2-Benzimidazole)pyrrolidine and 1-[2-(5-chloro) benzimadazole pyrrolidine dihydrochlorides had 5-HT3 antagonist activity equal to that of tropisetron..
Sobre autores
O. Zhukovskaya
Science Research Institute of Physical and Organic Chemistry, Southern Federal University
Autor responsável pela correspondência
Email: zhukowskaia.ol@yandex.ru
Rússia, Rostov-on-Don
V. Anisimova
Science Research Institute of Physical and Organic Chemistry, Southern Federal University
Email: zhukowskaia.ol@yandex.ru
Rússia, Rostov-on-Don
A. Spasov
Volgograd State Medical University, Ministry of Health of the Russian Federation; Volgograd Medical Scientific Center
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd; Volgograd
D. Yakovlev
Volgograd State Medical University, Ministry of Health of the Russian Federation; Volgograd Medical Scientific Center
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd; Volgograd
N. Gurova
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd
A. Kucheryavenko
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd
O. Salaznikova
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd
V. Kuznetsova
Volgograd State Medical University, Ministry of Health of the Russian Federation; Volgograd Medical Scientific Center
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd; Volgograd
D. Mal’tsev
Volgograd State Medical University, Ministry of Health of the Russian Federation; Volgograd Medical Scientific Center
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd; Volgograd
A. Brigadirova
Volgograd State Medical University, Ministry of Health of the Russian Federation; Volgograd Medical Scientific Center
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd; Volgograd
Ya. Morkovina
Volgograd Medical Scientific Center
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd
O. Solov’eva
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd
V. Gurova
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd
E. Reznikov
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: zhukowskaia.ol@yandex.ru
Rússia, Volgograd
