Comparative Evaluation of the Antiherpes Activity of Compounds with Different Mechanisms of Action
- Авторлар: Shadyro O.1, Sorokin V.1, Ksendzova G.1, Savinova O.1, Samovich S.1, Boreko E.2
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Мекемелер:
- Belarus State University
- Republican Scientific Applied Center for Epidemiology and Microbiology
- Шығарылым: Том 53, № 7 (2019)
- Беттер: 646-649
- Бөлім: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245920
- DOI: https://doi.org/10.1007/s11094-019-02055-3
- ID: 245920
Дәйексөз келтіру
Аннотация
Experiments on cell cultures addressed the antiviral properties of 2-anilino-4,6-di-tert-butylphenol and N-(3,5-di-tert-2-hydroxyphenyl)acetamide, both of which are o-aminophenol derivatives, and 3,4-dihydroxy-benzoic acid against herpes simplex virus and in experimental cutaneous herpes in white mice. Assessment of the data obtained here indicates that all three study compounds were significantly less active than acyclovir in cell cultures. In experiments on laboratory animals, the efficacy of ointment containing N-(3,5-di-tert-2-hydroxyphenyl) acetamide was comparable with that of acyclovir ointment, while ointments containing 2-anilino-4,6-di-tert-butylphenol and 3,4-dihydroxybenzoic acid were less active.
Авторлар туралы
O. Shadyro
Belarus State University
Хат алмасуға жауапты Автор.
Email: shadyro@open.by
Белоруссия, Minsk, 220030
V. Sorokin
Belarus State University
Email: shadyro@open.by
Белоруссия, Minsk, 220030
G. Ksendzova
Belarus State University
Email: shadyro@open.by
Белоруссия, Minsk, 220030
O. Savinova
Belarus State University
Email: shadyro@open.by
Белоруссия, Minsk, 220030
S. Samovich
Belarus State University
Email: shadyro@open.by
Белоруссия, Minsk, 220030
E. Boreko
Republican Scientific Applied Center for Epidemiology and Microbiology
Email: shadyro@open.by
Белоруссия, Minsk, 220114