Free Radical Scavenging and Cytotoxic Properties of Acylated and Non-Acylated Kaempferol Glycosides from Stenochlaena Palustris: a Perspective on Their Structure – Activity Relationships
- Авторлар: Chear N.1, Fauzi A.2, Khaw K.3, Choi S.4, Yaacob N.2, Lai C.1
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Мекемелер:
- Centre for Drug Research, Universiti Sains Malaysia
- Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia Health Campus
- Discipline of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia
- Malaysian Institute of Pharmaceuticals and Nutraceuticals, National Institutes of Biotechnology Malaysia, Ministry of Science, Technology and Innovation
- Шығарылым: Том 53, № 3 (2019)
- Беттер: 188-193
- Бөлім: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245677
- DOI: https://doi.org/10.1007/s11094-019-01977-2
- ID: 245677
Дәйексөз келтіру
Аннотация
Flavonoid glycosides that are present in acylated form have good prospect to be developed into therapeutic agents due to their improved biological properties, stability and physico-chemical properties compared to their maternal compounds. The present study aimed to compare the free radical scavenging and cytotoxic activities of a series of acylated and non-acylated kaempferol glycosides isolated from Stenochlaena palustris. The in silico binding interactions of the most cytotoxic glycoside with epidermal growth factor receptor was also evaluated. Results indicated that the free radical scavenging capability and cytotoxicity of kaempferol 3-O-β-D-glucopyranoside were enhanced through acylation with selected hydroxycinnamoyl groups, whereas mono-acylation did not improve both activities. Molecular docking study revealed that di-acylation was essential for the compound to bind to five major active sites of the receptor. Kaempferol 3-O-β-D-glucopyranosides that are di-acylated may be further explored for their chemopreventive and anticancer properties due to their significant antioxidant and cytotoxic properties.
Авторлар туралы
Nelson Chear
Centre for Drug Research, Universiti Sains Malaysia
Email: cs_lai@usm.my
Малайзия, Penang, 11800 USM
Agustine Fauzi
Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia Health Campus
Email: cs_lai@usm.my
Малайзия, Kubang Kerian, Kelantan, 16150
Kooi-Yeong Khaw
Discipline of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia
Email: cs_lai@usm.my
Малайзия, Penang, 11800 USM
Sy-Bing Choi
Malaysian Institute of Pharmaceuticals and Nutraceuticals, National Institutes of Biotechnology Malaysia, Ministry of Science, Technology and Innovation
Email: cs_lai@usm.my
Малайзия, Block 5-A, Halaman Bukit Gambir, Penang, 11700
Nik Yaacob
Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia Health Campus
Email: cs_lai@usm.my
Малайзия, Kubang Kerian, Kelantan, 16150
Choon-Sheen Lai
Centre for Drug Research, Universiti Sains Malaysia
Хат алмасуға жауапты Автор.
Email: cs_lai@usm.my
Малайзия, Penang, 11800 USM