Synthesis and Analgesic, Anthelmintic, and Insecticidal Activity of 3,3-Dialkyl-1-(2-Phenylamino-2-Thioxoethyl)-3,4-Dihydroisoquinolinium Chlorides
- Авторлар: Mikhailovskii A.1, Yusov A.1, Makhmudov R.2,3, Starkova A.1, Rudakova I.1
-
Мекемелер:
- Perm State Pharmaceutical Academy
- Perm State Research University
- Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
- Шығарылым: Том 52, № 8 (2018)
- Беттер: 716-720
- Бөлім: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245427
- DOI: https://doi.org/10.1007/s11094-018-1887-1
- ID: 245427
Дәйексөз келтіру
Аннотация
A series of 1,2,3,4-tetrahydroisoquinoline enaminothioamides were synthesized by reacting 1-methyl-3,3-dialkyl-3,4-dihydroisoquinolines with phenylisothiocyanate. Treatment of the obtained enamines with HCl gave 3,3-dialkyl-1-(2-phenylamino-2-thioxoethyl)-3,4-dihydroisoquinolinium chlorides. Benzo[f]isoquinoline derivatives were synthesized analogously. All hydrochlorides showed analgesic effects in the hot-plate test at the level of metamizole sodium. Isoquinolines with 6- and 7-alkoxy groups were most active. The hydrochloride of the thioamide containing benzo[f]isoquinoline and spirocyclopentane motifs had the greatest anthelmintic and insecticidal activities, which were similar to those of levamisole and diazinon.
Негізгі сөздер
Авторлар туралы
A. Mikhailovskii
Perm State Pharmaceutical Academy
Email: chem@folium.ru
Ресей, Perm, 614990
A. Yusov
Perm State Pharmaceutical Academy
Email: chem@folium.ru
Ресей, Perm, 614990
R. Makhmudov
Perm State Research University; Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Email: chem@folium.ru
Ресей, Perm, 614990; Perm, 614045
A. Starkova
Perm State Pharmaceutical Academy
Email: chem@folium.ru
Ресей, Perm, 614990
I. Rudakova
Perm State Pharmaceutical Academy
Email: chem@folium.ru
Ресей, Perm, 614990