Synthesis and Analgesic, Anthelmintic, and Insecticidal Activity of 3,3-Dialkyl-1-(2-Phenylamino-2-Thioxoethyl)-3,4-Dihydroisoquinolinium Chlorides
- Authors: Mikhailovskii A.G.1, Yusov A.S.1, Makhmudov R.R.2,3, Starkova A.V.1, Rudakova I.P.1
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Affiliations:
- Perm State Pharmaceutical Academy
- Perm State Research University
- Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
- Issue: Vol 52, No 8 (2018)
- Pages: 716-720
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245427
- DOI: https://doi.org/10.1007/s11094-018-1887-1
- ID: 245427
Cite item
Abstract
A series of 1,2,3,4-tetrahydroisoquinoline enaminothioamides were synthesized by reacting 1-methyl-3,3-dialkyl-3,4-dihydroisoquinolines with phenylisothiocyanate. Treatment of the obtained enamines with HCl gave 3,3-dialkyl-1-(2-phenylamino-2-thioxoethyl)-3,4-dihydroisoquinolinium chlorides. Benzo[f]isoquinoline derivatives were synthesized analogously. All hydrochlorides showed analgesic effects in the hot-plate test at the level of metamizole sodium. Isoquinolines with 6- and 7-alkoxy groups were most active. The hydrochloride of the thioamide containing benzo[f]isoquinoline and spirocyclopentane motifs had the greatest anthelmintic and insecticidal activities, which were similar to those of levamisole and diazinon.
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About the authors
A. G. Mikhailovskii
Perm State Pharmaceutical Academy
Email: chem@folium.ru
Russian Federation, Perm, 614990
A. S. Yusov
Perm State Pharmaceutical Academy
Email: chem@folium.ru
Russian Federation, Perm, 614990
R. R. Makhmudov
Perm State Research University; Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
Email: chem@folium.ru
Russian Federation, Perm, 614990; Perm, 614045
A. V. Starkova
Perm State Pharmaceutical Academy
Email: chem@folium.ru
Russian Federation, Perm, 614990
I. P. Rudakova
Perm State Pharmaceutical Academy
Email: chem@folium.ru
Russian Federation, Perm, 614990