Release Testing of Selected Drugs from Surface Magnetic Nanoparticles and Their Diffusion Through a Membrane
- Авторлар: Gronczewska E.1, Worobiec W.2, Defort A.2, Jurkowski A.1, Kozioł J.1,2
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Мекемелер:
- Faculty of Biological Sciences, University of Zielona Góra
- Innovation Center “Technologies for Human Health”, Science and Technology Park of Zielona Góra University Ltd.
- Шығарылым: Том 52, № 3 (2018)
- Беттер: 257-265
- Бөлім: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245113
- DOI: https://doi.org/10.1007/s11094-018-1803-8
- ID: 245113
Дәйексөз келтіру
Аннотация
In this study, magnetic nanoparticles were functionalized with dextran and immobilized ibuprofen, diclofenac, and dopamine in order to investigate the diffusion of drugs through a dialysis membrane under biological conditions such as a temperature of 37.0°C and pH 7.4. The concentration of released drugs was measured both inside the membrane and upon release into solution using spectrofluorimetric and spectrophotometric methods. The mechanism of drug release from the carrier was analyzed in terms of the Korsmeyer – Peppas model. The results show that differences in the mechanism of drug release depend on the time-diffusion process and the type of drug used. In addition, the atomic force microscopy and confocal microscopy methods were used to investigate the interaction between bacterial cells and functionalized nanoparticles.
Авторлар туралы
Ewelina Gronczewska
Faculty of Biological Sciences, University of Zielona Góra
Хат алмасуға жауапты Автор.
Email: vang@vp.pl
Польша, ul. Szafrana 1, Zielona Góra, 65 –516
Weronika Worobiec
Innovation Center “Technologies for Human Health”, Science and Technology Park of Zielona Góra University Ltd.
Email: vang@vp.pl
Польша, ul. Nowy Kisielin - A. Wysockiego 4, Zielona Góra, 66-002
Alicja Defort
Innovation Center “Technologies for Human Health”, Science and Technology Park of Zielona Góra University Ltd.
Email: vang@vp.pl
Польша, ul. Nowy Kisielin - A. Wysockiego 4, Zielona Góra, 66-002
Andrzej Jurkowski
Faculty of Biological Sciences, University of Zielona Góra
Email: vang@vp.pl
Польша, ul. Szafrana 1, Zielona Góra, 65 –516
Jacek Kozioł
Faculty of Biological Sciences, University of Zielona Góra; Innovation Center “Technologies for Human Health”, Science and Technology Park of Zielona Góra University Ltd.
Email: vang@vp.pl
Польша, ul. Szafrana 1, Zielona Góra, 65 –516; ul. Nowy Kisielin - A. Wysockiego 4, Zielona Góra, 66-002