Synthesis and Antifungal and Antiviral Activity of N-Benzyl Derivatives of the Tetraene Macrolide Antibiotic Lucensomycin
- Авторлар: Belakhov V.1, Garabadzhiu A.2, Kolodyaznaya V.3, Topkova O.3
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Мекемелер:
- Schulich Faculty of Chemistry, Technion – Israel Institute of Technology
- Laboratory of Molecular Pharmacology, St. Petersburg Technological Institute (Technical University)
- Department of Biotechnology, St. Petersburg State Chemical-Pharmaceutical Academy
- Шығарылым: Том 50, № 3 (2016)
- Беттер: 143-151
- Бөлім: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/244333
- DOI: https://doi.org/10.1007/s11094-016-1412-3
- ID: 244333
Дәйексөз келтіру
Аннотация
Reductive amination of the tetraene macrolide antibiotic lucensomycin by para-substituted benzaldehydes and cyanoborohydride formed its N-benzyl derivatives. The physicochemical, medical, and biological properties of the obtained pimaricin derivatives were studied. Biological tests showed that the N-benzyl lucensomycin derivatives possessed high antifungal and antiviral activity. Pharmacological tests showed that the acute toxicity (LD50) of the synthesized lucensomycin derivatives was six times less than that of the starting antibiotic.
Авторлар туралы
V. Belakhov
Schulich Faculty of Chemistry, Technion – Israel Institute of Technology
Email: chem@folium.ru
Израиль, Haifa
A. Garabadzhiu
Laboratory of Molecular Pharmacology, St. Petersburg Technological Institute (Technical University)
Email: chem@folium.ru
Ресей, St. Petersburg
V. Kolodyaznaya
Department of Biotechnology, St. Petersburg State Chemical-Pharmaceutical Academy
Email: chem@folium.ru
Ресей, St. Petersburg
O. Topkova
Department of Biotechnology, St. Petersburg State Chemical-Pharmaceutical Academy
Email: chem@folium.ru
Ресей, St. Petersburg