Cryosynthesis and Properties of Dehydroepiandrosterone Hormone Nanoparticles
- Авторлар: Morozov Y.1, Chistyakov D.2, Utekhina A.1, Astakhova A.2, Goncharov N.3, Sergeeva M.2, Sergeev G.1
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Мекемелер:
- Department of Chemistry, M. V. Lomonosov Moscow State University
- A. N. Belozerskii Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University
- Endocrinology Research Center, Russian Federation Ministry of Health
- Шығарылым: Том 49, № 12 (2016)
- Беттер: 813-816
- Бөлім: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244298
- DOI: https://doi.org/10.1007/s11094-016-1377-2
- ID: 244298
Дәйексөз келтіру
Аннотация
Nanoparticles of the steroidal hormone dihydroepiandrosterone (DHEA) were prepared by cryosynthesis technology, which allowed starting DHEA particles of size (100 ± 50) μm to be converted to nanoparticles of size (100 ± 20) nm. The particle sizes were determined by optical, electron transmission, and scanning atomic-force microscopy. HPLC with mass-spectrometric detection of starting and modified DHEA samples showed that the hormone molecular structure did not change during cryosynthesis of the nanoparticles. A comparison of the cytotoxicities of the samples on C6 glial cell culture showed that modified DHEA was less toxic. The results indicated that cryosynthesis technology could be used effectively to prepare nanoparticles of steroidal hormones.
Негізгі сөздер
Авторлар туралы
Yu. Morozov
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: chem@folium.ru
Ресей, Moscow, 119991
D. Chistyakov
A. N. Belozerskii Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University
Email: chem@folium.ru
Ресей, Moscow, 119234
A. Utekhina
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: chem@folium.ru
Ресей, Moscow, 119991
A. Astakhova
A. N. Belozerskii Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University
Email: chem@folium.ru
Ресей, Moscow, 119234
N. Goncharov
Endocrinology Research Center, Russian Federation Ministry of Health
Email: chem@folium.ru
Ресей, Moscow, 117036
M. Sergeeva
A. N. Belozerskii Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University
Email: chem@folium.ru
Ресей, Moscow, 119234
G. Sergeev
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: chem@folium.ru
Ресей, Moscow, 119991