Synthesis, Characterization and Antimicrobial Activity of Bis(Phthalimido)Piperazine and its Derivatives: a New Class of Bioactive Molecules with Enhanced Safety and Efficacy
- Authors: Aslam A.1, Abbas M.A.2, Iqbal M.3, Bashir S.1, Mehmood T.2,4, Kressler J.5
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Affiliations:
- Department of Pharmacy, University of Sargodha
- Department of Chemistry, University of Sargodha
- Department of Chemistry, School of Natural Sciences (SNS), National University of Sciences and Technology (NUST)
- Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences (UVAS)
- Department of Chemistry, Institute of Physical Chemistry, Martin Luther University of Halle-Wittenberg
- Issue: Vol 53, No 1 (2019)
- Pages: 43-47
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245601
- DOI: https://doi.org/10.1007/s11094-019-01953-w
- ID: 245601
Cite item
Abstract
Piperazine rings are important heterocyclic targets in organic synthesis and are useful synthetic intermediates or intricate parts of biologically active molecules. In our efforts, a series of piperazine derivatives has been prepared discovering new classes of antimicrobial agents, including bis(phthalimido)piperazine, bis(3-aminopropyl) piperazine, 2,3-dihydro-phthalazine-1,4-dione, and bis(3,4-aminophenol)piperazine. The synthesized antimicrobial agents have been studied using various spectroscopic techniques. Furthermore, these compounds have been screened for their in vitro antimicrobial activity against selected bacterial and fungal strains. Three compounds exhibited mild to good antibacterial activity, but somewhat lower antifungal activity against tested microbial strains.
About the authors
Afeefa Aslam
Department of Pharmacy, University of Sargodha
Email: mudassir.iqbal@sns.nust.edu.pk
Pakistan, Sargodha, 40100
Muhammad Azhar Abbas
Department of Chemistry, University of Sargodha
Email: mudassir.iqbal@sns.nust.edu.pk
Pakistan, Sargodha, 40100
Mudassir Iqbal
Department of Chemistry, School of Natural Sciences (SNS), National University of Sciences and Technology (NUST)
Author for correspondence.
Email: mudassir.iqbal@sns.nust.edu.pk
Pakistan, H-12, Islamabad
Sajid Bashir
Department of Pharmacy, University of Sargodha
Email: mudassir.iqbal@sns.nust.edu.pk
Pakistan, Sargodha, 40100
Tahir Mehmood
Department of Chemistry, University of Sargodha; Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences (UVAS)
Email: mudassir.iqbal@sns.nust.edu.pk
Pakistan, Sargodha, 40100; Lahore, 54000
Joerg Kressler
Department of Chemistry, Institute of Physical Chemistry, Martin Luther University of Halle-Wittenberg
Email: mudassir.iqbal@sns.nust.edu.pk
Germany, Halle (Saale), D-06120