Отправить статью по E-mail Control of the Dissolution Profile of Paracetamol from Carbomer Matrix Tablets
- Авторы: Son A.V.1, Filippova N.I.1, Vainshtein V.A.1
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Учреждения:
- St. Petersburg State Chemical-Pharmaceutical Academy
- Выпуск: Том 51, № 5 (2017)
- Страницы: 402-406
- Раздел: Drug Synthesis Methods and Manufacturing Technology
- URL: https://journals.rcsi.science/0091-150X/article/view/244627
- DOI: https://doi.org/10.1007/s11094-017-1622-3
- ID: 244627
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Аннотация
Results of experiments on prolonged release of paracetamol from polymer matrix tablets with cross-linked poly(acrylic acid) Carbopol® Ultrez 21 as the prolonging polymer were reported. The effects of factors such as tableting technology, type of alkaline agent, and ratio of Carbopol® to alkaline agent on paracetamol release kinetics were studied. It was established that matrices prepared by wet granulation had the best potential for prolonging the release. The ratio of Carbopol® to alkaline agent and their relative amounts also enabled the drug release rate to be prolonged.
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Об авторах
A. Son
St. Petersburg State Chemical-Pharmaceutical Academy
Автор, ответственный за переписку.
Email: mrandreson@mail.ru
Россия, 14 Prof. Popova St., St. Petersburg, 197022
N. Filippova
St. Petersburg State Chemical-Pharmaceutical Academy
Email: mrandreson@mail.ru
Россия, 14 Prof. Popova St., St. Petersburg, 197022
V. Vainshtein
St. Petersburg State Chemical-Pharmaceutical Academy
Email: mrandreson@mail.ru
Россия, 14 Prof. Popova St., St. Petersburg, 197022
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