Control of the Dissolution Profile of Paracetamol from Carbomer Matrix Tablets

Abstract

Results of experiments on prolonged release of paracetamol from polymer matrix tablets with cross-linked poly(acrylic acid) Carbopol^® Ultrez 21 as the prolonging polymer were reported. The effects of factors such as tableting technology, type of alkaline agent, and ratio of Carbopol^® to alkaline agent on paracetamol release kinetics were studied. It was established that matrices prepared by wet granulation had the best potential for prolonging the release. The ratio of Carbopol^® to alkaline agent and their relative amounts also enabled the drug release rate to be prolonged.