Complexes of Glucosamine Hydrochloride and Phytic Acid in Aqueous Medium and Their Antioxidant Properties in Human Blood Plasma

Abstract

The reaction in aqueous medium of phytic acid (myo-inositol hexakisphosphate) and glucosamine hydrochloride (2-amino-2-deoxy-β-D-glucopyranose hydrochloride) formed phytic acid—glucosamine complexes of formula InsP₆ 5GA. Their compositions were proved by elemental analysis for C, H, N, and P. IR, PMR, ¹³C NMR, and ³¹P NMR spectroscopy and potentiometric titration showed that the complexes of phytic acid and glucosamine were formed by H-bonds and electrostatic salt interactions. High antioxidant activity against lipid peroxidation and a positive effect on superoxide dismutase activity were found for complexes of InsP₆H₁₂ and glucosamine in in vitro studies of human blood plasma under oxidative stress.