Design, Synthesis, Drug-Likeness Studies and Bio-Evaluation of Some New Chalconeimines
- Authors: Rudrapal M.1, Sowmya M.P.1
-
Affiliations:
- Aditya Institute of Pharmaceutical Sciences and Research
- Issue: Vol 53, No 9 (2019)
- Pages: 814-821
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/246019
- DOI: https://doi.org/10.1007/s11094-019-02084-y
- ID: 246019
Cite item
Abstract
Newly designed chalconeimines were synthesized, characterized and evaluated for their in vitro antioxidant and antibacterial effectiveness. Results of antioxidant activity assay reveal that all the tested compounds possess good to moderate antioxidant activity which is lower in comparison to that of a standard drug (gallic acid). On the other hand, all the synthesized compounds were found to exhibit a considerably wider spectrum of antibacterial activity, but it was also narrower in comparison to that of a standard drug (ciprofloxacin). Elucidation of structure—activity relationships revealed that electron donating groups (-OH, -OCH3) contribute more to antioxidant potency, whereas electron withdrawing groups (-Cl) impart better antibacterial effectiveness. Moreover, results of drug-likeness studies indicate that a reasonable correlation exists between the drug-like properties and antioxidant activity of the synthesized chalconeimines.
About the authors
Mithun Rudrapal
Aditya Institute of Pharmaceutical Sciences and Research
Author for correspondence.
Email: rudrapal.m03@gmail.com
India, Surampalem, E.G. Dist., Andhra Pradesh, 533437
Mullapudi P. K. Sowmya
Aditya Institute of Pharmaceutical Sciences and Research
Email: rudrapal.m03@gmail.com
India, Surampalem, E.G. Dist., Andhra Pradesh, 533437