Synthesis and Antimicrobial Activity of 4-(4-Acetylphenyl)-3-Hydroxy-2 H -Chromen-2-One Derivatives

O. V. Rusnak; R. Z. Lytvyn; O. V. Skripskaya; O. O. Blinder; Kh. E. Pitkovych; P. I. Yagodinets; M. D. Obushak

doi:10.1007/s11094-019-02082-0

Synthesis and Antimicrobial Activity of 4-(4-Acetylphenyl)-3-Hydroxy-2H-Chromen-2-One Derivatives

Authors: Rusnak O.V.¹, Lytvyn R.Z.², Skripskaya O.V.¹, Blinder O.O.³, Pitkovych K.E.², Yagodinets P.I.¹, Obushak M.D.²
Affiliations:
1. Yu. Fedkovych Chernivtsi National University
2. Ivan Franko National University of Lviv
3. Bukovinian State Medical University
Issue: Vol 53, No 9 (2019)
Pages: 797-802
Section: Article
URL: https://journals.rcsi.science/0091-150X/article/view/246014
DOI: https://doi.org/10.1007/s11094-019-02082-0
ID: 246014

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Abstract

Reactions of 4-(4-bromoacetylphenyl)-3-hydroxy-2H-chromen-2-one with Py, 4-methylpyridine, quinoline, and benzo[f]quinoline produced quaternary salts; with dinucleophiles, derivatives of thiazole, imidazo[1,2-a]pyridine, and imidazo[1,2-a]pyrimidine. Several of the target compounds exhibited high antimicrobial activity that indicated further research on these compounds is warranted.