Development of Drug Substances of the Original Class III Antiarrhythmic Drugs Nibentan and Niferidyl


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Abstract

Publications on the design, synthesis, pharmacological research, and clinical trials of the Russian original class III antiarrhythmic drugs nibentan {(RS)-4-nitro-N-[1-phenyl-5-(diethylamino)pentyl]benzamide hydrochloride} and niferidyl {4-nitro-N-[(1RS)-1-(4-fluorophenyl)-2-(1-ethylpiperidin-4-yl)ethyl]benzamide hydrochloride}are reviewed.

About the authors

N. K. Davydova

A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences (INEOS RAN)

Author for correspondence.
Email: davydova@ineos.ac.ru
Russian Federation, 28 Vavilova St., Moscow, 119991


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