Email this article Antiproliferative Evaluation In Vitro of a New Chalcone Inducing Apoptosis by ROS Generation Against MGC-803 Cells
- Authors: Fu D.1, Li J.1, Li P.1, Cui Z.2,3, Zhang S.4, Li J.4
-
Affiliations:
- School of Pharmaceutical Sciences & Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University
- School of life Sciences, Institute of Biodiversity and Ecology, Zhengzhou University
- Charles Perkins Centre, Sydney Medical School, University of Sydney
- School of Basic Medicine, Zhengzhou University
- Issue: Vol 53, No 6 (2019)
- Pages: 539-543
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245855
- DOI: https://doi.org/10.1007/s11094-019-02034-8
- ID: 245855
Cite item
Open Access
Access granted
Subscription Access
Abstract
We have evaluated the antiproliferative activity of (E)-3-(3,5-difluorophenyl)-1-(2,4,6-trimethoxyphenyl)- prop-2-en-1-one (chalcone 5) against MGC-803 cells. This chalcone analog displayed a potent antiproliferative activity with an IC50 value of 0.23 μM against MGC-803 cells. It could induce apoptosis and regulate the apoptosis-related markers (Bax, Bcl-2, Bcl-xl, and Bid) in a concentration dependent manner. Treatment with NAC almost completely attenuated chalcone-induced cell inhibition and cell apoptosis in MGC-803 cells, indicating that the apoptotic mechanisms were related to ROS generation. Therefore, this chalcone derivative is a new apoptosis inducer for prevention and treatment of gastric cancer.
About the authors
Dong-Jun Fu
School of Pharmaceutical Sciences & Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University
Email: fade3532@163.com
China, Zhengzhou, 450001
Jia-Huan Li
School of Pharmaceutical Sciences & Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University
Email: fade3532@163.com
China, Zhengzhou, 450001
Ping Li
School of Pharmaceutical Sciences & Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University
Email: fade3532@163.com
China, Zhengzhou, 450001
Zhen-Wei Cui
School of life Sciences, Institute of Biodiversity and Ecology, Zhengzhou University; Charles Perkins Centre, Sydney Medical School, University of Sydney
Email: fade3532@163.com
China, Zhengzhou, 450001; Camperdown, Sydney, New South Wales, 2006
Sai-Yang Zhang
School of Basic Medicine, Zhengzhou University
Email: fade3532@163.com
China, Zhengzhou, 450001
Jiang-Feng Li
School of Basic Medicine, Zhengzhou University
Author for correspondence.
Email: fade3532@163.com
China, Zhengzhou, 450001
Supplementary files
