The Release of NSAIDs Such as Ibuprofen and Diclofenac from Magnetic Nanoparticles Coated with Dextran

Abstract

In this study, iron oxide (Fe₃O₄) nanoparticles were synthesized using the Massart co-precipitation method followed by surface coating with dextran. Next, coated magnetic nanoparticles (MNPs) were functionalized by diclofenac and dopamine attachment to the surface. The kinetics of release of these drugs was studied at various temperatures and pH of the medium. Concentrations of the released drugs were measured in vitro by spectrometric methods, and the mechanism of drug release from MNP carrier was analyzed in terms of the Korsmeyer – Peppas model. According to the results, the amount of released diclofenac and dopamine depended on the conditions, namely, temperature and pH of the medium. The values of the diffusion exponent n obtained for diclofenac suggest a Fickian diffusion mechanism, while the mechanism of dopamine diffusion was anomalous. These results were compared to those obtained previously for ibuprofen. The current results demonstrate differences in the mechanism of drug release under exposure to diverse environmental conditions.