Synthesis and Antiarrhythmic and Hemostatic Activity of [3,3-Dialkyl-3, 4-Dihydroisoquinolin-1(2H )-Ylidene]-N-Alkylacetamides

Abstract

[3,3-Dialkyl-3,4-dihydroisoqinolin-1(2H)-ylidene]-N-alkylacetamides were synthesized by reacting dialkylbenzylcarbinols with N-alkylcyanoacetamides. Hydrochlorides of the synthesized compounds existed in the imine form. All hydrochlorides showed antiarrhythmic and coagulant (hemostatic) effects. An amide with an unsubstituted amide N atom and a 3-spiro-cyclopentyl moiety was the most active compound with antiarrhythmic activity 2.8 times that of lidocaine and blood coagulation accelerated by 37.9%, which was 21.9% faster than etamsylate.