Synthesis and Neurotropic Activity of Piperazino-Derivatives of Pyrano[3,4-c]Pyridines
- Authors: Sirakanyan S.N.1, Akopyan É.K.1, Paronikyan R.G.1, Nazaryan I.M.1, Akopyan A.G.1, Ovakimyan A.A.1
-
Affiliations:
- A. I. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
- Issue: Vol 53, No 6 (2019)
- Pages: 495-499
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245831
- DOI: https://doi.org/10.1007/s11094-019-02026-8
- ID: 245831
Cite item
Abstract
Methods were developed for synthesizing new substituted piperazine derivatives from chloropyrano- [3,4-c]pyridines. Pharmacological screening of the synthesized compounds used the well-known corazole antagonism and open field tests. The rotating rod test was used to evaluate the neurotoxicity of the compounds. The tested compounds displayed neurotropic activity. Several compounds of this series exhibited pronounced anticonvulsant and anxiolytic activity.
About the authors
S. N. Sirakanyan
A. I. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Author for correspondence.
Email: shnnr@mail.ru
Armenia, 0014, Yerevan, 375014
É. K. Akopyan
A. I. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: shnnr@mail.ru
Armenia, 0014, Yerevan, 375014
R. G. Paronikyan
A. I. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: shnnr@mail.ru
Armenia, 0014, Yerevan, 375014
I. M. Nazaryan
A. I. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: shnnr@mail.ru
Armenia, 0014, Yerevan, 375014
A. G. Akopyan
A. I. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: shnnr@mail.ru
Armenia, 0014, Yerevan, 375014
A. A. Ovakimyan
A. I. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: shnnr@mail.ru
Armenia, 0014, Yerevan, 375014