Email this article Synthesis and Antioxidant and Anti-Influenza Activity of Aminomethanesulfonic Acids
- Authors: Khoma R.E.1,2, Gelmboldt V.O.2, Énnan A.A.1, Gridina T.L.3,1, Fedchuk A.S.4,1, Lozitsky V.P.4, Rakipov I.M.5, Vladyka A.S.3
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Affiliations:
- Physical-Chemical Institute for Environmental and Human Protection, Ministry of Education and Science and National Academy of Sciences of Ukraine
- I. I. Mechnikov Odessa National University
- Odessa National Medical University
- Odessa Research Center Biomedical Testing of Food and Drugs
- A. V. Bogatsky Physical-Chemical Institute, National Academy of Sciences of Ukraine
- Issue: Vol 53, No 5 (2019)
- Pages: 436-439
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245799
- DOI: https://doi.org/10.1007/s11094-019-02016-w
- ID: 245799
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Abstract
Aminomethanesulfonic acid (I) and its N-methyl- (II), N-(2-hydroxy)ethyl- (III), N-(tert-butyl)- (IV), N-benzyl- (V), and 4-(N-phenylaminomethyl)phenyl- (VI) derivatives (V and VI not previously reported) were synthesized and characterized by elemental analysis and IR and mass spectroscopy. The in vitro antioxidant activities of aminomethanesulfonic acids I-VI were found to be comparatively weak. Compounds IV and V suppressed statistically significantly reproduction of influenza virus strains A/Hong Kong/1/68 (H3N2) and A/PR/8/34 (H1N1) in chorioallantoic membrane tissue culture.
About the authors
R. E. Khoma
Physical-Chemical Institute for Environmental and Human Protection, Ministry of Education and Science and National Academy of Sciences of Ukraine; I. I. Mechnikov Odessa National University
Author for correspondence.
Email: rek@onu.edu.ua
Ukraine, Odessa, 65082; Odessa
V. O. Gelmboldt
I. I. Mechnikov Odessa National University
Email: rek@onu.edu.ua
Ukraine, Odessa
A. A. Énnan
Physical-Chemical Institute for Environmental and Human Protection, Ministry of Education and Science and National Academy of Sciences of Ukraine
Email: rek@onu.edu.ua
Ukraine, Odessa, 65082
T. L. Gridina
Odessa National Medical University; Physical-Chemical Institute for Environmental and Human Protection, Ministry of Education and Science and National Academy of Sciences of Ukraine
Email: rek@onu.edu.ua
Ukraine, Odessa, 65082; Odessa, 65082
A. S. Fedchuk
Odessa Research Center Biomedical Testing of Food and Drugs; Physical-Chemical Institute for Environmental and Human Protection, Ministry of Education and Science and National Academy of Sciences of Ukraine
Email: rek@onu.edu.ua
Ukraine, Odessa, 65003; Odessa, 65082
V. P. Lozitsky
Odessa Research Center Biomedical Testing of Food and Drugs
Email: rek@onu.edu.ua
Ukraine, Odessa, 65003
I. M. Rakipov
A. V. Bogatsky Physical-Chemical Institute, National Academy of Sciences of Ukraine
Email: rek@onu.edu.ua
Ukraine, Odessa
A. S. Vladyka
Odessa National Medical University
Email: rek@onu.edu.ua
Ukraine, Odessa, 65082
