Improved Process for Zoledronic Acid Synthesis
- Authors: Kuvaeva Z.I.1, Lopatik D.V.1, Bondareva O.M.1
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Affiliations:
- Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus
- Issue: Vol 53, No 3 (2019)
- Pages: 264-266
- Section: Drug Synthesis Methods and Manufacturing Technology
- URL: https://journals.rcsi.science/0091-150X/article/view/245722
- DOI: https://doi.org/10.1007/s11094-019-01989-y
- ID: 245722
Cite item
Abstract
Zoledronic acid is the drug substance of the highly efficient antiresorptive medicine Zometa. An improved synthesis of zoledronic acid via bis-phosphonation of 2-(1H-imidazol-1-yl)acetic acid is reported.
About the authors
Z. I. Kuvaeva
Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus
Email: aminoacid1@ifoch.bas-net.by
Belarus, Minsk
D. V. Lopatik
Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus
Author for correspondence.
Email: aminoacid1@ifoch.bas-net.by
Belarus, Minsk
O. M. Bondareva
Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus
Email: aminoacid1@ifoch.bas-net.by
Belarus, Minsk