Email this article Synthesis and Pharmacological Properties of N-Decyltropine (IEM-1556) as Compared to Selective Nicotinic Receptor Antagonist Tert-Butyldecylammonium (IEM-1678)
- Authors: Gmiro V.E.1, Serdyuk S.E.1
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Affiliations:
- Institute of Experimental Medicine
- Issue: Vol 53, No 3 (2019)
- Pages: 212-215
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245695
- DOI: https://doi.org/10.1007/s11094-019-01981-6
- ID: 245695
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Abstract
The property profile of N-decyltropine (IEM-1556) has significant advantages over that of its prototype, the selective nicotinic receptor antagonist tert-butyldecylammonium (IEM-1678), because its anticonvulsant, antiparkinsonian, antidepressant, and analgesic activities are significantly greater and its therapeutic index is 2.8 times higher than that of IEM-1678. The higher pharmacological activity and lower toxicity of IEM-1556 are explained by the fact that IEM-1556 not only blocks nicotinic receptors but also stimulates subdiaphragmatic vagal afferents.
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About the authors
V. E. Gmiro
Institute of Experimental Medicine
Author for correspondence.
Email: gmiro2119@gmail.com
Russian Federation, 12 Acad. Pavlov St., St. Petersburg, 197376
S. E. Serdyuk
Institute of Experimental Medicine
Email: gmiro2119@gmail.com
Russian Federation, 12 Acad. Pavlov St., St. Petersburg, 197376
