Synthesis and Pharmacological Activity of C(2)-Substituted Benzimidazoles
- Authors: Zhukovskaya O.N.1, Spasov A.A.2,3, Yakovlev D.S.2,3, Kosolapov V.A.2, Mal’tsev D.V.2,3, Morkovnik A.S.1, Babkova V.A.2, Brigadirova A.A.2,3, Agatsarskaya Y.V.2,3, Taran A.S.2, Miroshnikov M.V.2, Sultanova K.T.2, Kornilov V.I.2, Anisimova V.A.1
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Affiliations:
- Institute of Physical and Organic Chemistry, Southern Federal University
- Volgograd State Medical University, Ministry of Health of the RF
- Volgograd Medical Scientific Center
- Issue: Vol 53, No 3 (2019)
- Pages: 201-206
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245683
- DOI: https://doi.org/10.1007/s11094-019-01979-0
- ID: 245683
Cite item
Abstract
Series of new compounds containing 2-pyrrolidinomethyl and 2-piperazinomethyl groups and 2-morpholino and 2-morpholinoethylamine substituents were synthesized. The antiglycation activities of 2-(morpholin-4-yl)-1-(propen-2-en-1-yl)-1H-benzimidazole and 2-(morpholin-4-yl)-1-[2-(morpholin-4-yl)ethyl]-1H-benzimidazole were comparable to that of aminoguanidine. Some compounds exhibited moderate antiserotonin, anti-angiotensin, antioxidant, and dipeptidyl peptidase-4 (DPP-4) inhibitory effects.
About the authors
O. N. Zhukovskaya
Institute of Physical and Organic Chemistry, Southern Federal University
Author for correspondence.
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Rostov-on-Don, 344090
A. A. Spasov
Volgograd State Medical University, Ministry of Health of the RF; Volgograd Medical Scientific Center
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131; Volgograd, 400131
D. S. Yakovlev
Volgograd State Medical University, Ministry of Health of the RF; Volgograd Medical Scientific Center
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131; Volgograd, 400131
V. A. Kosolapov
Volgograd State Medical University, Ministry of Health of the RF
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131
D. V. Mal’tsev
Volgograd State Medical University, Ministry of Health of the RF; Volgograd Medical Scientific Center
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131; Volgograd, 400131
A. S. Morkovnik
Institute of Physical and Organic Chemistry, Southern Federal University
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Rostov-on-Don, 344090
V. A. Babkova
Volgograd State Medical University, Ministry of Health of the RF
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131
A. A. Brigadirova
Volgograd State Medical University, Ministry of Health of the RF; Volgograd Medical Scientific Center
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131; Volgograd, 400131
Ya. V. Agatsarskaya
Volgograd State Medical University, Ministry of Health of the RF; Volgograd Medical Scientific Center
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131; Volgograd, 400131
A. S. Taran
Volgograd State Medical University, Ministry of Health of the RF
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131
M. V. Miroshnikov
Volgograd State Medical University, Ministry of Health of the RF
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131
K. T. Sultanova
Volgograd State Medical University, Ministry of Health of the RF
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131
V. I. Kornilov
Volgograd State Medical University, Ministry of Health of the RF
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Volgograd, 400131
V. A. Anisimova
Institute of Physical and Organic Chemistry, Southern Federal University
Email: zhukowskaia.ol@yandex.ru
Russian Federation, Rostov-on-Don, 344090