Iron-Binding and Iron-Reducing Properties of Material Based on Collagen and Taxifolin (Dihydroquercetin) Under Physiological and Pathophysiological Conditions
- Authors: Shatalin Y.V.1,2, Shubina V.S.1,2
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Affiliations:
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences (ITEB RAS)
- Pushchino State Institute of Natural Sciences
- Issue: Vol 53, No 2 (2019)
- Pages: 165-169
- Section: Drug Synthesis Methods and Manufacturing Technology
- URL: https://journals.rcsi.science/0091-150X/article/view/245659
- DOI: https://doi.org/10.1007/s11094-019-01972-7
- ID: 245659
Cite item
Abstract
The properties of gels prepared from collagen and the natural polyphenol taxifolin were studied. The degradation rate of the gel was shown to decrease with increasing fraction of functionalized taxifolin in it. Gel including polyphenol exhibited iron(II)-binding and iron(III)-reducing activity whereas polyphenol released from the gel could reduce iron ions but did not exhibit significant iron-binding activity. Oxidative modification of the gel increased the polyphenol release rate and decreased its metal-binding properties. In general, the results suggested that stable gels could be produced from collagen and taxifolin and could exhibit antioxidant activity by binding iron ions.
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About the authors
Yu. V. Shatalin
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences (ITEB RAS); Pushchino State Institute of Natural Sciences
Author for correspondence.
Email: yury.shatalin@yandex.ru
Russian Federation, 3 Institutskaya St., Pushchino, Moscow, Oblast, 142290; 3 Nauki Prosp., Pushchino, Moscow, Oblast, 142290
V. S. Shubina
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences (ITEB RAS); Pushchino State Institute of Natural Sciences
Email: yury.shatalin@yandex.ru
Russian Federation, 3 Institutskaya St., Pushchino, Moscow, Oblast, 142290; 3 Nauki Prosp., Pushchino, Moscow, Oblast, 142290