Synthesis, Physicochemical Properties, and Antimicrobial Activity of Polymyxin B1 Conjugates with Polyglutaraldehyde

Abstract

Polymyxin B₁ conjugates with polyglutaraldehyde were synthesized using reductive amination. The synthesized polymeric antibiotic derivatives were tested for antimicrobial activity against Gram-negative and Gram-positive bacteria. Polymyxin B₁ was found to be stable under the reaction conditions. The main structural factors influencing the antimicrobial activity of these conjugates were the composition and structure of the polyglutaraldehyde polymer chain. The polymer-antibiotic conjugates were very soluble in aqueous solutions and organic solvents.