Inhibition of α-Amylase and α-Glucosidase by New β-Aminopropionamidoxime Derivatives
- Authors: Kayukova L.A.1, Uzakova A.B.1, Baitursynova G.P.1, Dyusembaeva G.T.1, Shul’gau Z.T.2, Gulyaev A.E.2,3, Sergazy S.D.2,3
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Affiliations:
- A. B. Bekturov Institute of Chemical Sciences
- National Center for Biotechnology
- Center for Life Sciences, Nazarbayev University
- Issue: Vol 53, No 2 (2019)
- Pages: 129-133
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245634
- DOI: https://doi.org/10.1007/s11094-019-01966-5
- ID: 245634
Cite item
Abstract
New antidiabetic agents are being sought because of the global problem with diabetes. Amidoxime derivatives are known to have antidiabetic activity. β-Aminopropionamidoxime bases and pharmacologically acceptable salts of O-aroyl-β-(morpholin-1-yl)propionamidoximes and 5-substituted phenyl-3-β-(piperidin-1-yl and morpholin-1-yl)ethyl-1,2,4-oxadiazoles were screened in vitro for antidiabetic activity manifested as inhibition of α-amylase and α-glucosidase. Compounds with pronounced antidiabetic properties were identified. The series of 3,5-disubstituted 1,2,4-oxadiazoles were more active than the series of O-aroyl-β-aminopropionamidoximes. The results could be used for further in vivo screening of the antidiabetic properties of the most promising compounds with a preliminary assessment of their mean toxic doses in animals.
About the authors
L. A. Kayukova
A. B. Bekturov Institute of Chemical Sciences
Author for correspondence.
Email: kayukova@mail.ru
Kazakhstan, Almaty
A. B. Uzakova
A. B. Bekturov Institute of Chemical Sciences
Email: kayukova@mail.ru
Kazakhstan, Almaty
G. P. Baitursynova
A. B. Bekturov Institute of Chemical Sciences
Email: kayukova@mail.ru
Kazakhstan, Almaty
G. T. Dyusembaeva
A. B. Bekturov Institute of Chemical Sciences
Email: kayukova@mail.ru
Kazakhstan, Almaty
Z. T. Shul’gau
National Center for Biotechnology
Email: kayukova@mail.ru
Kazakhstan, Astana
A. E. Gulyaev
National Center for Biotechnology; Center for Life Sciences, Nazarbayev University
Email: kayukova@mail.ru
Kazakhstan, Astana; Astana
Sh. D. Sergazy
National Center for Biotechnology; Center for Life Sciences, Nazarbayev University
Email: kayukova@mail.ru
Kazakhstan, Astana; Astana