Synthesis and Anti-Ischemic Activity in Rats of Substituted N-Benzyl 1,2,5-Trimethyl-, 2,2,6,6-Tetramethylpiperidyl-, and Tropylamines

I. B. Tsorin; M. B. Vititnova; V. N. Stolyaruk; L. M. Kostochka; S. A. Kryzhanovskii

doi:10.1007/s11094-019-01963-8

Synthesis and Anti-Ischemic Activity in Rats of Substituted N-Benzyl 1,2,5-Trimethyl-, 2,2,6,6-Tetramethylpiperidyl-, and Tropylamines

Authors: Tsorin I.B.¹, Vititnova M.B.¹, Stolyaruk V.N.¹, Kostochka L.M.¹, Kryzhanovskii S.A.¹
Affiliations:
1. V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Issue: Vol 53, No 2 (2019)
Pages: 113-117
Section: Article
URL: https://journals.rcsi.science/0091-150X/article/view/245626
DOI: https://doi.org/10.1007/s11094-019-01963-8
ID: 245626

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Abstract

Series of benzylidene and benzyl derivatives of 1,2,5-trimethyl-, 2,2,6,6-tetramethylpiperidyl-, and tropylamines were synthesized and screened for anti-ischemic activity in rats. The lead compound was identified as 2,2,6,6-tetramethyl-N-(3,4,5-trimethoxybenzyl)piperidin-4-amine, the anti-ischemic activity of which was statistically significantly greater than that of the reference drug trimetazidine in a myocardial subendocardial ischemia model.