Email this article Synthesis and Pharmacological Properties of 1-(6-Aminohexylamino)-1-Phenylcyclohexyl Dihydrochloride (IEM-2062) as Compared with Memantine
- Authors: Gmiro V.E.1, Serdyuk S.E.1, Veselkina O.S.2
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Affiliations:
- Institute of Experimental Medicine
- ZAO Vertex Pharmaceutical Company
- Issue: Vol 53, No 1 (2019)
- Pages: 29-34
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245596
- DOI: https://doi.org/10.1007/s11094-019-01950-z
- ID: 245596
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Abstract
1-(6-Aminohexylamino)-1-phenylcyclohexyl dihydrochloride (IEM-2062) had significantly greater antihypoxic, anticonvulsant, antidepressant, and analgesic activity than memantine and similar antiparkinsonism activity as memantine; it had low toxicity and was safer for use. IEM-2062 produced significant pharmacological effects in the dose range 0.3 – 3 mg/kg.
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About the authors
V. E. Gmiro
Institute of Experimental Medicine
Author for correspondence.
Email: gmiro2119@gmail.com
Russian Federation, 12 Academician Pavlov Street, St. Petersburg, 197376
S. E. Serdyuk
Institute of Experimental Medicine
Email: gmiro2119@gmail.com
Russian Federation, 12 Academician Pavlov Street, St. Petersburg, 197376
O. S. Veselkina
ZAO Vertex Pharmaceutical Company
Email: gmiro2119@gmail.com
Russian Federation, 27A 24th Line, Vasilevskii Ostrov, St. Petersburg, 199106
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