Email this article In Vitro Evaluation of Drug Content in and Drug Release Kinetics from Stents with Different Types of Polymer Coating
- Authors: Prostyakova A.I.1, Zybin D.I.2, Kapustin D.V.1
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Affiliations:
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Institute of Fine Chemical Technologies, Moscow Technological University
- Issue: Vol 52, No 12 (2019)
- Pages: 1011-1015
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245582
- DOI: https://doi.org/10.1007/s11094-019-01943-y
- ID: 245582
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Abstract
Drug elution profiles must be studied in vitro to optimize a polymer-drug formulation during development of drug-eluting stents (DESs). Results from HPLC assays of drug contents and elution kinetics from a biodegradable sirolimus coating and a stable zotarolimus coating on coronary DESs are presented. Drug contents were assessed for crimped stents on the delivery system and expanded stents. The drug coating morphology and elution kinetics were demonstrated to be associated. Significant coating morphological defects were shown to cause deviations in the drug elution profile.
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About the authors
A. I. Prostyakova
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: kapustin@ibch.ru
Russian Federation, 16/10 Miklukho-Maklaya St., Moscow, 117997
D. I. Zybin
Institute of Fine Chemical Technologies, Moscow Technological University
Email: kapustin@ibch.ru
Russian Federation, 86 Prosp. Vernadskogo, Moscow, 119571
D. V. Kapustin
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Author for correspondence.
Email: kapustin@ibch.ru
Russian Federation, 16/10 Miklukho-Maklaya St., Moscow, 117997
