DAD Based Stability Indicating RP-UPLC Method for Simultaneous Determination of Olmesartan Medoxomil and Amlodipine Besylate

Abstract

Stability indicating RP-UPLC-DAD method for simultaneous determination of olmesartan medoxomil (OLM) and amlodipine besylate (AML) in tablet dosage forms has been developed. The method was fully validated, showing satisfactory data for all suitability parameters tested. The study of degradation products showed that OLM and ALM are more stable with respect to thermolysis and photolysis than under other stress-induced degradation conditions. The proposed stability indicating method can be applied in pharmaceutical analysis for drug stability monitoring and quality control.