Chemical Enhancers or Transcutaneous Conductors: Transcutol
- Authors: Strusovskaya O.G.1,2, Poroiskii S.V.1,2, Strusovskaya A.G.1
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Affiliations:
- Volgograd State Medical University, Ministry of Health of the Russian Federation
- Volgograd Medical Scientific Center
- Issue: Vol 52, No 11 (2019)
- Pages: 879-884
- Section: Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
- URL: https://journals.rcsi.science/0091-150X/article/view/245523
- DOI: https://doi.org/10.1007/s11094-019-01920-5
- ID: 245523
Cite item
Abstract
The concept of enhancers or transcutaneous conductors and their classification and mechanism of action are discussed. Special attention is paid to transcutol, a conductor with pronounced solubilizing and penetrating properties that facilitates the accumulation of locally applied medicines in the skin lipid layer without perturbing its structure. The transcutaneous action effectiveness of chemical enhancers is shown to depend on not only the structure and concentration but also the physicochemical characteristics of the penetrating drugs. Diffusional transport in the stratum corneum and the ability to monitor the occurring processes can be used to optimize the design of drugs for transcutaneous targeted delivery.
Keywords
About the authors
O. G. Strusovskaya
Volgograd State Medical University, Ministry of Health of the Russian Federation; Volgograd Medical Scientific Center
Author for correspondence.
Email: strol3@yandex.ru
Russian Federation, Volgograd, 400131; Volgograd, 400131
S. V. Poroiskii
Volgograd State Medical University, Ministry of Health of the Russian Federation; Volgograd Medical Scientific Center
Email: strol3@yandex.ru
Russian Federation, Volgograd, 400131; Volgograd, 400131
A. G. Strusovskaya
Volgograd State Medical University, Ministry of Health of the Russian Federation
Email: strol3@yandex.ru
Russian Federation, Volgograd, 400131