Physicochemical Properties and Analytical Method Development for Drug Substance of GML-1, a Novel Original Anxiolytic Preparation

L. M. Gaevaya; L. N. Grushevskaya; M. S. Sergeeva; A. A. Illarionov; N. I. Avdyunina; B. M. Pyatin; F. S. Baiburtskii; G. V. Mokrov

doi:10.1007/s11094-018-1901-7

Physicochemical Properties and Analytical Method Development for Drug Substance of GML-1, a Novel Original Anxiolytic Preparation

Authors: Gaevaya L.M.¹, Grushevskaya L.N.¹, Sergeeva M.S.¹, Illarionov A.A.¹, Avdyunina N.I.¹, Pyatin B.M.¹, Baiburtskii F.S.¹, Mokrov G.V.¹
Affiliations:
1. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Issue: Vol 52, No 9 (2018)
Pages: 790-795
Section: Structure of Chemical Compounds, Method of Analysis and Process Control
URL: https://journals.rcsi.science/0091-150X/article/view/245467
DOI: https://doi.org/10.1007/s11094-018-1901-7
ID: 245467

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Abstract

The physicochemical properties of the novel original anxiolytic GML-1 drug substance were studied, analytical techniques for it were developed, and its main pharmacopoeial quality parameters were determined using IR spectroscopy, UV spectrophotometry, HPLC, and the Kjeldahl method.