Local Analgesic Activity of Hemantane Gel Dosage Forms Evaluated Using the Formalin Test in Rats
- Authors: Ivanova E.A.1, Matyushkin A.I.1, Blynskaya E.V.1, Voronina T.A.1
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Affiliations:
- V. V. Zakusov Institute of Pharmacology
- Issue: Vol 52, No 8 (2018)
- Pages: 740-743
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245436
- DOI: https://doi.org/10.1007/s11094-018-1890-6
- ID: 245436
Cite item
Abstract
Hemantane is an antiparkinsonian drug with pronounced analgesic and anti-inflammatory properties. The present work evaluated topical gel dosage forms based on it for analgesic activity. It was found that gel batches 070916, 080916, and 090916 exhibited analgesic activity using the formalin test in rats and diminished behavior characteristic of pain in the inflammation-mediated tonic phase of formalin-induced pain. 5% hemantane gel batch 080916 exhibited the most distinct analgesic activity because this dosage form decreased pain indicators even in the acute phase related to the effect of formalin on primary pain afferents.
Keywords
About the authors
E. A. Ivanova
V. V. Zakusov Institute of Pharmacology
Author for correspondence.
Email: iwanowaea@yandex.ru
Russian Federation, Moscow
A. I. Matyushkin
V. V. Zakusov Institute of Pharmacology
Email: iwanowaea@yandex.ru
Russian Federation, Moscow
E. V. Blynskaya
V. V. Zakusov Institute of Pharmacology
Email: iwanowaea@yandex.ru
Russian Federation, Moscow
T. A. Voronina
V. V. Zakusov Institute of Pharmacology
Email: iwanowaea@yandex.ru
Russian Federation, Moscow