Email this article Automated Synthesis of [18F]Fluoromethylcholine for Positron-Emission Tomography Imaging
- Authors: Fedorova O.S.1,2, Vaitekhovich F.P.3, Krasikova R.N.1,2
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Affiliations:
- N. P. Bekhtereva Institute of Human Brain, Russian Academy of Sciences
- St. Petersburg State University
- GE Healthcare Co.
- Issue: Vol 52, No 8 (2018)
- Pages: 730-734
- Section: Drug Synthesis Methods and Manufacturing Technology
- URL: https://journals.rcsi.science/0091-150X/article/view/245434
- DOI: https://doi.org/10.1007/s11094-018-1889-z
- ID: 245434
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Abstract
Automated technology for synthesizing [18F]fluoromethylcholine, a radiopharmaceutical for diagnostic positron-emission-tomography tumor imaging, was developed. A TRACERlab FXFN synthesis module (GE Healthcare) used the combined technology of on-line alkylation and solid-phase extraction. The synthesis module was modified to allow operation at various He flow rates in critical process steps. The radiochemical yield of [18F]fluoromethylcholine was >10%, which was sufficient to produce several clinical doses. The quality control parameters of the produced [18F]fluoromethylcholine met the requirements of the RF Pharmacopoeia.
About the authors
O. S. Fedorova
N. P. Bekhtereva Institute of Human Brain, Russian Academy of Sciences; St. Petersburg State University
Author for correspondence.
Email: fedorova@ihb.spb.ru
Russian Federation, St. Petersburg, 197376; St. Petersburg, 199034
F. P. Vaitekhovich
GE Healthcare Co.
Email: fedorova@ihb.spb.ru
Russian Federation, Moscow, 123317
R. N. Krasikova
N. P. Bekhtereva Institute of Human Brain, Russian Academy of Sciences; St. Petersburg State University
Email: fedorova@ihb.spb.ru
Russian Federation, St. Petersburg, 197376; St. Petersburg, 199034
