Reductive Amination of Sterically Hindered Arylaminoketones Using a Modified Leuckart Reaction
- Authors: Skachilova S.Y.1, Zheltukhin N.K.1, Sergeev V.N.2, Davydova N.K.2
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Affiliations:
- All-Russia Center for Safety Testing of Biologically Active Substances (ARC BAS)
- A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences (INEOS RAN)
- Issue: Vol 52, No 6 (2018)
- Pages: 545-549
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245319
- DOI: https://doi.org/10.1007/s11094-018-1857-7
- ID: 245319
Cite item
Abstract
The Leuckart reaction offers a fast and convenient method for synthesizing various formamides, amines, and large numbers of biologically active compounds and pharmaceuticals. New 5-(N-piperidino)-1-arylpentan-1-ones (1a-f) and 5-(N-piperidino)-1-aryl-1-aminopentanes (2a-f) were synthesized. The properties of starting aminoketones 1a-f for synthesizing arylaminoketones 2a-f under Leuckart reaction conditions and their thermal stability over a broad temperature interval were studied. The optimal conditions for the key synthetic step, i.e., the Leuckart reaction, were determined experimentally.
Keywords
About the authors
S. Ya. Skachilova
All-Russia Center for Safety Testing of Biologically Active Substances (ARC BAS)
Email: davydova@ineos.ac.ru
Russian Federation, 23 Kirov St., Staraya Kupavna, Moscow Oblast, 142450
N. K. Zheltukhin
All-Russia Center for Safety Testing of Biologically Active Substances (ARC BAS)
Email: davydova@ineos.ac.ru
Russian Federation, 23 Kirov St., Staraya Kupavna, Moscow Oblast, 142450
V. N. Sergeev
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences (INEOS RAN)
Email: davydova@ineos.ac.ru
Russian Federation, 28 Vavilov St, Moscow, 119991
N. K. Davydova
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences (INEOS RAN)
Author for correspondence.
Email: davydova@ineos.ac.ru
Russian Federation, 28 Vavilov St, Moscow, 119991