Synthesis and Antiproliferative Activity of Imidazole and Triazole Derivatives of Flavonoids

Abstract

Flavones can play a potential role in estrogen dependent breast cancer due to greater reactivity of imidazole and triazole heterocycles which have been investigated in this work. We emphasized on synthesis of flavones derivatives with imidazole (2a, 2b, 2c) and triazole (3a, 3b, 3c) nucleus as a fundamental hetero-aromatic system with modifications, which have been confirmed by TLC, IR, NMR and mass spectrometry data. The synthesized compound were studied as non-steroidal aromatase inhibitors and evaluated for in vitro anti-breast cancer activity against MCF-7 cell line through SRB assay. The triazole derivative 3a with nitro substitution (H-bond accepting group) was found to be more active in comparison to standard drug letrozole.