Email this article Optimization of Culture Conditions for the Production of Lovastatin by Aspergillus Terreus in Submerged Fermentation
- Authors: Azeem M.1,2, Saleem Y.2, Hussain Z.1, Zahoor S.3, Javed M.M.1
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Affiliations:
- Institute of Industrial Biotechnology, Government College University
- Food and Biotechnology Research Centre, Pakistan Council of Scientific and Industrial Research
- Department of Biotechnology, Virtual University of Pakistan
- Issue: Vol 52, No 3 (2018)
- Pages: 284-289
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245134
- DOI: https://doi.org/10.1007/s11094-018-1807-4
- ID: 245134
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Abstract
The production of lovastatin by Aspergillus terreus PU-PCSIR-1 was studied using submerged fermentation technique. Effects of pH, incubation temperature, incubation time, and the media components on the production of lovastatin were investigated. Maximum lovastatin yield (198.90 mg/L) was achieved after 14 days of incubation at temperature 28°C and pH 7.4. Peptonized milk, linoleic acid, glucose, yeast extract, and trace elements had a positive impact on the production of lovastatin by A. terreus.
About the authors
M. Azeem
Institute of Industrial Biotechnology, Government College University; Food and Biotechnology Research Centre, Pakistan Council of Scientific and Industrial Research
Email: mmj_bot@yahoo.com
Pakistan, Lahore; Lahore
Y. Saleem
Food and Biotechnology Research Centre, Pakistan Council of Scientific and Industrial Research
Email: mmj_bot@yahoo.com
Pakistan, Lahore
Z. Hussain
Institute of Industrial Biotechnology, Government College University
Email: mmj_bot@yahoo.com
Pakistan, Lahore
S. Zahoor
Department of Biotechnology, Virtual University of Pakistan
Email: mmj_bot@yahoo.com
Pakistan, Lahore
M. M. Javed
Institute of Industrial Biotechnology, Government College University
Author for correspondence.
Email: mmj_bot@yahoo.com
Pakistan, Lahore
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