Email this article Approaches to Pharmaceutical Analysis of an Innovative Liposomal Preparation for Treating Hepatitis C
- Authors: Smirnov V.V.1,2,3, Krasnykh L.M.1, Shilovskii I.P.2, Ryzhenkova A.P.3, Khaitov M.R.2, Drozdov V.N.3
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Affiliations:
- Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
- Institute of Immunology, Federal Medico-Biological Agency of the Russian Federation
- I. M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
- Issue: Vol 52, No 3 (2018)
- Pages: 254-256
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245109
- DOI: https://doi.org/10.1007/s11094-018-1802-9
- ID: 245109
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Abstract
The composite Y14/siUTR, a complex consisting of cationic lipopeptide Y14 as an excipient and pharmaceutical substance of small interfering RNAtargeted against the UTR region of hepatitis C virus (siUTR), was investigated. The composite was intended to inhibit the hepatitis C virus replication cycle. The present work was aimed at developing pharmaceutical analytical methods for the components of this composite using HPLC-UV and UV spectroscopy.
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About the authors
V. V. Smirnov
Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation; Institute of Immunology, Federal Medico-Biological Agency of the Russian Federation; I. M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Email: chem@folium.ru
Russian Federation, 8/2 Petrovskii Blvd., Moscow, 127051; Moscow, 115478; Moscow, 119991
L. M. Krasnykh
Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, 8/2 Petrovskii Blvd., Moscow, 127051
I. P. Shilovskii
Institute of Immunology, Federal Medico-Biological Agency of the Russian Federation
Email: chem@folium.ru
Russian Federation, Moscow, 115478
A. P. Ryzhenkova
I. M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Email: chem@folium.ru
Russian Federation, Moscow, 119991
M. R. Khaitov
Institute of Immunology, Federal Medico-Biological Agency of the Russian Federation
Email: chem@folium.ru
Russian Federation, Moscow, 115478
V. N. Drozdov
I. M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Email: chem@folium.ru
Russian Federation, Moscow, 119991
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