Email this article Comparative Dissolution Kinetics of Ibuprofen 200-Mg Capsules (Medisorb Co., Russia) and Ibuprofen 200-Mg Coated Tablets (Biosynthesis Co., Russia)
- Authors: Prozorova N.A.1,2, Vdovina G.P.1, Bobrov A.V.2
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Affiliations:
- E. A. Wagner Perm State Medical University
- Medisorb Co.
- Issue: Vol 52, No 3 (2018)
- Pages: 245-247
- Section: Structure of Chemical Compounds, Methods of Analysis and Process Control
- URL: https://journals.rcsi.science/0091-150X/article/view/245103
- DOI: https://doi.org/10.1007/s11094-018-1800-y
- ID: 245103
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Abstract
Experimental data on the comparative dissolution kinetics of two ibuprofen preparations from different manufacturers are presented. The study was performed in three buffer solutions at pH 1.2, 4.5, and 6.8 according to requirements of the Scientific Center for Expert Evaluation of Medicinal Products of the Russian Federation. A fourth dissolution medium was buffer solution at pH 7.2, which is included in a draft regulation. The test used a Erweka DT-720 rotating-basket device.
Keywords
About the authors
N. A. Prozorova
E. A. Wagner Perm State Medical University; Medisorb Co.
Author for correspondence.
Email: prosorova_n@mail.ru
Russian Federation, 26 Petropavlovskaya St., Perm, 614000; 6 Gal’perina St., Perm, 614113
G. P. Vdovina
E. A. Wagner Perm State Medical University
Email: prosorova_n@mail.ru
Russian Federation, 26 Petropavlovskaya St., Perm, 614000
A. V. Bobrov
Medisorb Co.
Email: prosorova_n@mail.ru
Russian Federation, 6 Gal’perina St., Perm, 614113
