Email this article Anisotropic Iron-Oxide Nanoparticles for Diagnostic MRI: Synthesis and Contrast Properties
- Authors: Nikitin A.A.1,2, Khramtsov M.A.1, Savchenko A.G.1, Abakumov M.A.1,3, Mazhuga A.G.2,4
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Affiliations:
- National University of Science and Technology MISIS (Moscow Institute of Steel and Alloys)
- Department of Chemistry, M. V. Lomonosov Moscow State University
- N. I. Pirogov Russian National Research Medical University
- D. I. Mendeleev University of Chemical Technology of Russia
- Issue: Vol 52, No 3 (2018)
- Pages: 231-235
- Section: Drug Synthesis Methods and Manufacturing Technology
- URL: https://journals.rcsi.science/0091-150X/article/view/245090
- DOI: https://doi.org/10.1007/s11094-018-1796-3
- ID: 245090
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Abstract
The scientific and technical literature addressing the synthesis of anisotropic iron-oxide nanoparticles of various shapes (cubic, rod-like, clustered, etc.) sized from 10 to 100 nm and their application for diagnostic magnetic resonance imaging (MRI) of tissues and organs is analyzed. The analysis indicates that the nanoparticle shape, size, and surface chemistry affect considerably relaxation parameters T1 and T2. Thus, cubic iron-oxide nanoparticles had the greatest T2 values. Furthermore, rod-like and octapodal nanoparticles also exhibit rather high T2 values so that they can be used as contrast agents for diagnostic MRI.
About the authors
A. A. Nikitin
National University of Science and Technology MISIS (Moscow Institute of Steel and Alloys); Department of Chemistry, M. V. Lomonosov Moscow State University
Author for correspondence.
Email: nikitin.chemistry@mail.ru
Russian Federation, 4 Leninskii Prosp., Moscow, 119991; 1/3 Leninskie Gory, GSP-1, Moscow, 119991
M. A. Khramtsov
National University of Science and Technology MISIS (Moscow Institute of Steel and Alloys)
Email: nikitin.chemistry@mail.ru
Russian Federation, 4 Leninskii Prosp., Moscow, 119991
A. G. Savchenko
National University of Science and Technology MISIS (Moscow Institute of Steel and Alloys)
Email: nikitin.chemistry@mail.ru
Russian Federation, 4 Leninskii Prosp., Moscow, 119991
M. A. Abakumov
National University of Science and Technology MISIS (Moscow Institute of Steel and Alloys); N. I. Pirogov Russian National Research Medical University
Email: nikitin.chemistry@mail.ru
Russian Federation, 4 Leninskii Prosp., Moscow, 119991; 1 Ostrovityanova, Moscow, 119997
A. G. Mazhuga
Department of Chemistry, M. V. Lomonosov Moscow State University; D. I. Mendeleev University of Chemical Technology of Russia
Email: nikitin.chemistry@mail.ru
Russian Federation, 1/3 Leninskie Gory, GSP-1, Moscow, 119991; 9 Miusskaya Sq., Moscow, 125047
