Email this article Analgesic Activity of a Polypeptide Modulator of TRPV1 Receptors
- Authors: D’yachenko I.A.1,2,3, Belous G.I.1,3, Skobtsova L.A.1,3, Zharmukhamedova T.Y.1,3, Palikov V.A.1,3, Palikova Y.A.1,3, D’yachenko E.V.1,3, Kalabina E.A.1, Rudenko V.B.1, Andreev Y.A.4,5, Logashina Y.A.4,5, Kozlov S.A.4, Yavorskii A.N.3,6, Murashev A.N.1,2,3
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Affiliations:
- Pushchino Branch of the Shemyakin—Ovchinnikov Institute of Bioorganic Chemistry (BIBC), Russian Academy of Sciences
- Pushchino Scientific Center, Russian Academy of Sciences
- Pushchino State Institute of Natural Sciences
- Shemyakin—Ovchinnikov Institute of Bioorganic Chemistry (IBC), Russian Academy of Sciences
- Institute of Molecular Medicine, I. M. Sechenov First Moscow State Medical University
- Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Health of the Russian Federation
- Issue: Vol 52, No 3 (2018)
- Pages: 213-215
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245083
- DOI: https://doi.org/10.1007/s11094-018-1793-6
- ID: 245083
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Abstract
The activity of APHC2, a new polypeptide modulator of TRPV1 receptors that was isolated from Heteractis crispa, is studied. It was established that APHC2 possessed analgesic properties, did not disturb normal locomotor activity, and did not change body temperature and hemostasis of experimental animals. These attributes could be of great practical value for designing a new generation of efficacious analgesics. A brief increase of heart rate was observed during studies of the hemodynamic activity. Further investigation of the binding specifics of this polypeptide with TRPV1 receptors could open approaches to discovering other antagonists of these receptors.
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About the authors
I. A. D’yachenko
Pushchino Branch of the Shemyakin—Ovchinnikov Institute of Bioorganic Chemistry (BIBC), Russian Academy of Sciences; Pushchino Scientific Center, Russian Academy of Sciences; Pushchino State Institute of Natural Sciences
Author for correspondence.
Email: dyachenko@bibch.ru
Russian Federation, 6 Prosp. Nauki, Pushchino, Moscow Oblast, 142290; 3 Prosp. Nauki, Pushchino, Moscow Oblast, 142290; 3 Prosp. Nauki, Pushchino, Moscow Oblast, 142290
G. I. Belous
Pushchino Branch of the Shemyakin—Ovchinnikov Institute of Bioorganic Chemistry (BIBC), Russian Academy of Sciences; Pushchino State Institute of Natural Sciences
Email: dyachenko@bibch.ru
Russian Federation, 6 Prosp. Nauki, Pushchino, Moscow Oblast, 142290; 3 Prosp. Nauki, Pushchino, Moscow Oblast, 142290
L. A. Skobtsova
Pushchino Branch of the Shemyakin—Ovchinnikov Institute of Bioorganic Chemistry (BIBC), Russian Academy of Sciences; Pushchino State Institute of Natural Sciences
Email: dyachenko@bibch.ru
Russian Federation, 6 Prosp. Nauki, Pushchino, Moscow Oblast, 142290; 3 Prosp. Nauki, Pushchino, Moscow Oblast, 142290
T. Yu. Zharmukhamedova
Pushchino Branch of the Shemyakin—Ovchinnikov Institute of Bioorganic Chemistry (BIBC), Russian Academy of Sciences; Pushchino State Institute of Natural Sciences
Email: dyachenko@bibch.ru
Russian Federation, 6 Prosp. Nauki, Pushchino, Moscow Oblast, 142290; 3 Prosp. Nauki, Pushchino, Moscow Oblast, 142290
V. A. Palikov
Pushchino Branch of the Shemyakin—Ovchinnikov Institute of Bioorganic Chemistry (BIBC), Russian Academy of Sciences; Pushchino State Institute of Natural Sciences
Email: dyachenko@bibch.ru
Russian Federation, 6 Prosp. Nauki, Pushchino, Moscow Oblast, 142290; 3 Prosp. Nauki, Pushchino, Moscow Oblast, 142290
Yu. A. Palikova
Pushchino Branch of the Shemyakin—Ovchinnikov Institute of Bioorganic Chemistry (BIBC), Russian Academy of Sciences; Pushchino State Institute of Natural Sciences
Email: dyachenko@bibch.ru
Russian Federation, 6 Prosp. Nauki, Pushchino, Moscow Oblast, 142290; 3 Prosp. Nauki, Pushchino, Moscow Oblast, 142290
E. V. D’yachenko
Pushchino Branch of the Shemyakin—Ovchinnikov Institute of Bioorganic Chemistry (BIBC), Russian Academy of Sciences; Pushchino State Institute of Natural Sciences
Email: dyachenko@bibch.ru
Russian Federation, 6 Prosp. Nauki, Pushchino, Moscow Oblast, 142290; 3 Prosp. Nauki, Pushchino, Moscow Oblast, 142290
E. A. Kalabina
Pushchino Branch of the Shemyakin—Ovchinnikov Institute of Bioorganic Chemistry (BIBC), Russian Academy of Sciences
Email: dyachenko@bibch.ru
Russian Federation, 6 Prosp. Nauki, Pushchino, Moscow Oblast, 142290
V. B. Rudenko
Pushchino Branch of the Shemyakin—Ovchinnikov Institute of Bioorganic Chemistry (BIBC), Russian Academy of Sciences
Email: dyachenko@bibch.ru
Russian Federation, 6 Prosp. Nauki, Pushchino, Moscow Oblast, 142290
Ya. A. Andreev
Shemyakin—Ovchinnikov Institute of Bioorganic Chemistry (IBC), Russian Academy of Sciences; Institute of Molecular Medicine, I. M. Sechenov First Moscow State Medical University
Email: dyachenko@bibch.ru
Russian Federation, 16/10 Miklukho-Maklaya St., Moscow, 117997; 8 Trubetskaya St., Moscow, 119991
Yu. A. Logashina
Shemyakin—Ovchinnikov Institute of Bioorganic Chemistry (IBC), Russian Academy of Sciences; Institute of Molecular Medicine, I. M. Sechenov First Moscow State Medical University
Email: dyachenko@bibch.ru
Russian Federation, 16/10 Miklukho-Maklaya St., Moscow, 117997; 8 Trubetskaya St., Moscow, 119991
S. A. Kozlov
Shemyakin—Ovchinnikov Institute of Bioorganic Chemistry (IBC), Russian Academy of Sciences
Email: dyachenko@bibch.ru
Russian Federation, 16/10 Miklukho-Maklaya St., Moscow, 117997
A. N. Yavorskii
Pushchino State Institute of Natural Sciences; Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Health of the Russian Federation
Email: dyachenko@bibch.ru
Russian Federation, 3 Prosp. Nauki, Pushchino, Moscow Oblast, 142290; 8 Petrovskii Blvd., Moscow, 127051
A. N. Murashev
Pushchino Branch of the Shemyakin—Ovchinnikov Institute of Bioorganic Chemistry (BIBC), Russian Academy of Sciences; Pushchino Scientific Center, Russian Academy of Sciences; Pushchino State Institute of Natural Sciences
Email: dyachenko@bibch.ru
Russian Federation, 6 Prosp. Nauki, Pushchino, Moscow Oblast, 142290; 3 Prosp. Nauki, Pushchino, Moscow Oblast, 142290; 3 Prosp. Nauki, Pushchino, Moscow Oblast, 142290
